The function of OXR1 (oxidation resistance 1, ENSG00000164830) is as follows. Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (PubMed:38593795). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V- ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (By similarity). Involved in protection from oxidative damage (PubMed:11114193, PubMed:15060142). Protects neuronal cells from oxidative stress (By similarity). {ECO:0000250|UniProtKB:Q4KMM3, ECO:0000269|PubMed:11114193, ECO:0000269|PubMed:15060142, ECO:0000269|PubMed:38593795}.