The function of GPR146 (G protein-coupled receptor 146, ENSG00000164849) is as follows. G protein-coupled receptor required for the regulation of plasma cholesterol levels (PubMed:31778654, PubMed:38503280). Receptor for CHLSN, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed:38503280). {ECO:0000269|PubMed:31778654, ECO:0000269|PubMed:38503280}.