Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:12239222, PubMed:30420639). Could also be permeable to urea (By similarity). Also participates in cell permeability to H2O2 and H2O2- mediated signaling (PubMed:20724658). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair (By similarity). In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity). {ECO:0000250|UniProtKB:P47862, ECO:0000250|UniProtKB:Q8R2N1, ECO:0000269|PubMed:12239222, ECO:0000269|PubMed:20724658, ECO:0000269|PubMed:30420639}. This is the function of Ensembl gene identifier ENSG00000165272 (AQP3, aquaporin 3 (Gill blood group)).