The function of Ensembl gene identifier ENSG00000165501 (LRR1, leucine rich repeat protein 1) is as follows. Substrate recognition subunit of an ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S- phase (By similarity). May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1 (PubMed:11804328). {ECO:0000250|UniProtKB:D3YY91, ECO:0000269|PubMed:11804328, ECO:0000269|PubMed:15601820}.