The function of ENSG00000165548 (TMEM63C, transmembrane protein 63C) is as follows. Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress (PubMed:24503647, PubMed:35718349). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes (PubMed:35718349). In particular may regulate mitochondrial motility and function in motor neuron axons (PubMed:35718349). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). {ECO:0000250|UniProtKB:D3ZNF5, ECO:0000269|PubMed:24503647, ECO:0000269|PubMed:35718349, ECO:0000269|PubMed:39716028}.