Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration. . This is the function of ADAMTS15 (ADAM metallopeptidase with thrombospondin type 1 motif 15, ENSG00000166106).