The function of TAC3 (tachykinin precursor 3, Ensembl gene identifier ENSG00000166863) is as follows. Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. [Neurokinin-B]: Is a ligand for TACR3, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:37391393). Binding to TACR3 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). Is a critical central regulator of gonadal function (By similarity) (PubMed:19079066). {ECO:0000250|UniProtKB:P08435, ECO:0000269|PubMed:19079066, ECO:0000269|PubMed:37391393}.