Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin- dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). . This is the function of PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma, ENSG00000166908).