Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044). Has some preference toward medium-chain substrates (PubMed:17762044). Plays a role in adipocyte differentiation (PubMed:16380219). . This is the function of Ensembl gene identifier ENSG00000167107 (ACSF2, acyl-CoA synthetase family member 2).