Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (PubMed:33147462, PubMed:36594413). Plays a role in the late phase response of TLR-induced immune effector expression (By similarity). During influenza infection, interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex (PubMed:33147462). Inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation (PubMed:36594413). Strong transcriptional coactivator (PubMed:10982866). {ECO:0000250|UniProtKB:Q9ERC3, ECO:0000269|PubMed:10982866, ECO:0000269|PubMed:33147462, ECO:0000269|PubMed:36594413}. This is the function of Ensembl gene identifier ENSG00000167565 (SERTAD3, SERTA domain containing 3).