The function of ENSG00000167608 (TMC4, transmembrane channel like 4) is as follows. Voltage-gated chloride channel involved in high-concentration salt taste sensation (PubMed:34429071, PubMed:34468713). Depolarization induced by high NaCl concentration may trigger the activation of TMC4- mediated chloride influx into taste bud cells, helping the return to resting potential (PubMed:34429071). Also allows permeation of organic anions including gluconate, but their current amplitudes at positive potentials are less than that of chloride (PubMed:34429071). Involved in pH and temperature-dependent modulation of salty taste (PubMed:34468713). {ECO:0000269|PubMed:34429071, ECO:0000269|PubMed:34468713}.