Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate. . [Isoform 3]: Ca(2+)-independent, swelling-activated chloride channel, possibly involved in regulation of cell volume. . This is the function of TTYH1 (tweety family member 1, ENSG00000167614).