The function of ENSG00000167642 (SPINT2, serine peptidase inhibitor, Kunitz type 2) is as follows. Inhibitor of HGFAC (PubMed:9346890). Also inhibits plasmin, and plasma and tissue kallikrein (PubMed:9115294). Inhibits serine protease activity of TMPRSS13 (PubMed:20977675, PubMed:28710277). Inhibits serine protease activity of ST14/matriptase and PRSS8/prostasin in vitro (PubMed:28710277, PubMed:30445423). {ECO:0000269|PubMed:20977675, ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:30445423, ECO:0000269|PubMed:9115294, ECO:0000269|PubMed:9346890}.