Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells. . This is the function of ENSG00000167968 (DNASE1L2, deoxyribonuclease 1 like 2).