The function of Ensembl gene identifier ENSG00000168081 (PNOC, prepronociceptin) is as follows. [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. . [Nocistatin]: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. . [Orphanin FQ2]: Has potent analgesic activity. .