Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell- matrix interactions and regulate the motility of cells via interactions with integrins. . [Isoform 2]: May act as alpha-secretase for amyloid precursor protein (APP). . This is the function of ADAM9 (ADAM metallopeptidase domain 9, Ensembl gene identifier ENSG00000168615).