The function of NR0B1 (nuclear receptor subfamily 0 group B member 1, Ensembl gene identifier ENSG00000169297) is as follows. Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions (PubMed:12482977, PubMed:32433991). Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis (PubMed:7990953, PubMed:8675564). May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). {ECO:0000250|UniProtKB:Q61066, ECO:0000269|PubMed:12482977, ECO:0000269|PubMed:32433991, ECO:0000269|PubMed:7990953, ECO:0000269|PubMed:8675564}.