The function of GPR25 (G protein-coupled receptor 25, Ensembl gene identifier ENSG00000170128) is as follows. Receptor for the C-X-C chemokine CXCL17, which plays a key role in lymphocyte homing (PubMed:39293486, PubMed:40279398). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway (PubMed:39293486). Activation by CXCL17 on lymphocytes activates the RhoA pathway, which regulates cytoskeletal dynamics and integrins, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts (PubMed:39293486). .