The function of ADPRM (ADP-ribose/CDP-alcohol diphosphatase, manganese dependent, ENSG00000170222) is as follows. Hydrolyzes ADP-ribose, ADP, CDP-glycerol, CDP-choline, CDP- ethanolamine and cyclic ADP-ribose (cADPR), but not other non-reducing ADP-sugars or CDP-glucose (PubMed:25692488). May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity). {ECO:0000250|UniProtKB:Q5M886, ECO:0000269|PubMed:25692488}.