The function of ZNF282 (zinc finger protein 282, Ensembl gene identifier ENSG00000170265) is as follows. Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'- TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.