The function of HS6ST2 (heparan sulfate 6-O-sulfotransferase 2, ENSG00000171004) is as follows. 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. .