The function of FBXW10 (F-box and WD repeat domain containing 10, Ensembl gene identifier ENSG00000171931) is as follows. Probable substrate-recognition component of a SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. .