The function of SYNPO (synaptopodin, Ensembl gene identifier ENSG00000171992) is as follows. Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). .