The function of GPR22 (G protein-coupled receptor 22, Ensembl gene identifier ENSG00000172209) is as follows. Orphan G protein-coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (PubMed:18539757). May be involved in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:A0A2R9YJI3, ECO:0000269|PubMed:18539757}.