The function of ENSG00000172361 (CFAP53, cilia and flagella associated protein 53) is as follows. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Regulates motility patterns of both 9+0 and 9+2 motile cilia through differential localization and recruitment of axonemal dynein components (By similarity). Required for centriolar satellite integrity and non-motile cilium assembly (PubMed:26538025). Required for motile cilium formation (PubMed:26538025). Through its role in the beating of primary cilia, involved in the establishment of organ laterality during embryogenesis (PubMed:26531781). Required for sperm flagellum biogenesis and is essential for male fertility (By similarity). {ECO:0000250|UniProtKB:F1N7G5, ECO:0000250|UniProtKB:Q9D439, ECO:0000269|PubMed:26531781, ECO:0000269|PubMed:26538025, ECO:0000269|PubMed:36191189}.