The function of ENSG00000172780 (RAB43, RAB43, member RAS oncogene family) is as follows. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16086013, PubMed:17562788, PubMed:17684057, PubMed:18664496, PubMed:21255211, PubMed:29069590). Involved in retrograde transport from the endocytic pathway to the Golgi apparatus (PubMed:17684057). Required for the structural integrity of the Golgi complex (PubMed:17684057, PubMed:18664496). Also controls the anterograde ER-to-Golgi transport of nascent G protein-coupled receptors (including ADRA2A, ADRA2B, ADRA2C, ADRA1B, ADRB2 and AGTR1) and regulates the ER sorting of GPCR members by virtue of its ability to interact directly (PubMed:18664496, PubMed:29069590). Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network (PubMed:17562788). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:16086013, ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:17684057, ECO:0000269|PubMed:18664496, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:29069590}.