Acts as a tumor suppressor in lung cancer (PubMed:26056045, PubMed:36355209). Inhibits tumor cell growth by inhibiting cell proliferation and migration and promoting cell apoptosis (PubMed:26056045, PubMed:36355209). Inhibits metastasis of lung cancer by suppressing beta-catenin expression in the Wnt/beta-catenin signaling pathway (By similarity). {ECO:0000250|UniProtKB:D3YWQ9, ECO:0000269|PubMed:26056045, ECO:0000269|PubMed:36355209}. This is the function of TMEM196 (transmembrane protein 196, ENSG00000173452).