The function of SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2, ENSG00000175356) is as follows. Lipid-binding protein carrier required for sonic hedgehog (SHH) long-range signaling: binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) and promotes its release from producing cells, allowing it to act as a morphogen for distant signaling (PubMed:19480626, PubMed:22677548, PubMed:22902404, PubMed:35231446). ShhN is then transferred to the CDON-BOC heterodimer and GAS1 coreceptors to reach its target, the patched receptor (PTCH1 or PTCH2), followed by activation of the smoothened signaling pathway (PubMed:35231446). May also enhance the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687). {ECO:0000269|PubMed:19480626, ECO:0000269|PubMed:22677548, ECO:0000269|PubMed:22902404, ECO:0000269|PubMed:24522195, ECO:0000269|PubMed:27834687, ECO:0000269|PubMed:35231446}.