The function of KCNE5 (potassium voltage-gated channel subfamily E regulatory subunit 5, ENSG00000176076) is as follows. Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta- subunit of the repolarizing cardiac potassium ion channel KCNQ1. .