The function of FBXO46 (F-box protein 46, ENSG00000177051) is as follows. Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins (PubMed:30171069). In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR- phosphorylated FBXO31 (PubMed:30171069). .