The function of Ensembl gene identifier ENSG00000179603 (GRM8, glutamate metabotropic receptor 8) is as follows. G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. .