G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:23999500, PubMed:35041514). Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells (PubMed:23999500). In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways (PubMed:35041514). Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage (By similarity). {ECO:0000250|UniProtKB:P56484, ECO:0000269|PubMed:10540332, ECO:0000269|PubMed:23999500, ECO:0000269|PubMed:35041514, ECO:0000269|PubMed:9207005, ECO:0000269|PubMed:9469461, ECO:0000269|PubMed:9521068}. (Microbial infection) Acts as a coreceptor for HIV-1 and HIV- 2 viruses. . (Microbial infection) Acts as a receptor for Kaposi virus protein vCCL1/K6 and thereby inhibits apoptosis in the targeted cells. . This is the function of CCR8 (C-C motif chemokine receptor 8, ENSG00000179934).