The function of NKX2-6 (NK2 homeobox 6, Ensembl gene identifier ENSG00000180053) is as follows. Acts as a transcriptional activator (PubMed:15649947). In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development. {ECO:0000250|UniProtKB:P43688, ECO:0000269|PubMed:15649947}.