The function of CHRM2 (cholinergic receptor muscarinic 2, Ensembl gene identifier ENSG00000181072) is as follows. Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia (PubMed:24256733, PubMed:3443095, PubMed:36690613). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:36690613). CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity (PubMed:36690613). {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095, ECO:0000269|PubMed:36690613}.