The function of UTS2R (urotensin 2 receptor, ENSG00000181408) is as follows. G protein-coupled receptor for the vasoactive neuropeptides urotensin-2 and urotensin-2B (PubMed:14550283). Upon ligand binding, activates intracellular signaling cascades via G protein coupling, primarily through Gq/11, leading to phospholipase C activation, increased intracellular calcium, and activation of protein kinase C (PKC) (PubMed:18314227). Through coupling to G(i)/G(o) alpha subunits, stimulates MAPK/ERK pathways and thereby contributes to regulation of vascular tone, cardiac contractility, and cell proliferation (PubMed:12503613, PubMed:14753294). Ligand binding also triggers a marked reduction in the biogenesis of autophagosomes by inhibiting the recruitment of ATG16L1 to pre-autophagosomal endocytic vesicles (PubMed:27715446). {ECO:0000269|PubMed:12503613, ECO:0000269|PubMed:14550283, ECO:0000269|PubMed:14753294, ECO:0000269|PubMed:18314227, ECO:0000269|PubMed:27715446}.