The function of ACSM5 (acyl-CoA synthetase medium chain family member 5, Ensembl gene identifier ENSG00000183549) is as follows. Acyl-CoA synthetase that catalyzes the ATP-dependent activation of fatty acids to their corresponding acyl-CoA thioesters, the first committed step in fatty acid metabolism (By similarity). Negatively regulates lipid accumulation via inhibition of FABP4- PPARgamma signaling (PubMed:37957699). {ECO:0000250|UniProtKB:Q08AH1, ECO:0000269|PubMed:37957699}.