E3 ubiquitin-protein ligase (PubMed:27667714). Positively regulates the NF-kappa-B signaling pathway (PubMed:27667714, PubMed:28073078). {ECO:0000269|PubMed:27667714, ECO:0000269|PubMed:28073078}. (Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non- structural protein 2 (NS2A) and targets it for proteasome-mediated degradation. . This is the function of ENSG00000183718 (TRIM52, tripartite motif containing 52).