Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines (PubMed:19679103, PubMed:25026888). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances. In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (By similarity). {ECO:0000250|UniProtKB:Q8BZT5, ECO:0000269|PubMed:19679103, ECO:0000269|PubMed:25026888}. This is the function of Ensembl gene identifier ENSG00000184434 (LRRC19, leucine rich repeat containing 19).