The function of ENSG00000184988 (TMEM106A, transmembrane protein 106A) is as follows. Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro- inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:29131025, PubMed:30456879). {ECO:0000250|UniProtKB:Q8VC04, ECO:0000269|PubMed:29131025, ECO:0000269|PubMed:30456879}.