The function of ANKS1B (ankyrin repeat and sterile alpha motif domain containing 1B, ENSG00000185046) is as follows. Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}. Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.