Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). {ECO:0000269|PubMed:11294880, ECO:0000269|PubMed:26631410}. This is the function of SLC24A3 (solute carrier family 24 member 3, Ensembl gene identifier ENSG00000185052).