The function of Ensembl gene identifier ENSG00000185231 (MC2R, melanocortin 2 receptor) is as follows. G protein-coupled receptor for corticotropin/ACTH, primarily expressed in adrenal cortex where it plays a key role in the regulation of adrenocortical function (PubMed:1325670, PubMed:17596328, PubMed:36588120). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway, the MAPK cascade as well as the PKA pathway, leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation (PubMed:1325670). Activation by ACTH facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone (PubMed:12213892, PubMed:8636348). In addition, MC2R is required for fetal and neonatal adrenal gland development (By similarity). {ECO:0000250|UniProtKB:Q64326, ECO:0000269|PubMed:12213892, ECO:0000269|PubMed:1325670, ECO:0000269|PubMed:17596328, ECO:0000269|PubMed:36588120, ECO:0000269|PubMed:8636348}.