E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus (PubMed:23131556, PubMed:30142214, PubMed:31375575, PubMed:31578292). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection (PubMed:30844644). In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity (PubMed:36251989). Also plays a role in cataract formation together with TP53 (PubMed:30844644). Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination (PubMed:30844644). Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 (PubMed:37739411). {ECO:0000269|PubMed:23131556, ECO:0000269|PubMed:30142214, ECO:0000269|PubMed:30844644, ECO:0000269|PubMed:31375575, ECO:0000269|PubMed:31578292, ECO:0000269|PubMed:36251989, ECO:0000269|PubMed:37739411}. This is the function of TRIM69 (tripartite motif containing 69, Ensembl gene identifier ENSG00000185880).