The function of PDE2A (phosphodiesterase 2A, Ensembl gene identifier ENSG00000186642) is as follows. cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15938621, PubMed:29392776, PubMed:9210593). Has a higher efficiency with cGMP compared to cAMP (PubMed:15938621). Plays a role in cell growth and migration (PubMed:24705027). {ECO:0000269|PubMed:15938621, ECO:0000269|PubMed:24705027, ECO:0000269|PubMed:29392776, ECO:0000269|PubMed:9210593}. [Isoform PDE2A2]: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA- dependent phosphorylation of DNM1L (PubMed:28463107). .