The function of Ensembl gene identifier ENSG00000186652 (PRG2, proteoglycan 2, pro eosinophil major basic protein) is as follows. Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. .