G protein-coupled receptor for neuropeptide S (NPS) (PubMed:15947423, PubMed:16720571, PubMed:16790440). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C- activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels (PubMed:15312648, PubMed:15947423, PubMed:16720571, PubMed:16790440, PubMed:25714705, PubMed:26865629). In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction (PubMed:26865629). Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade (PubMed:26865629). Inhibits cell growth in response to NPS binding (PubMed:15947423). {ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16720571, ECO:0000269|PubMed:16790440, ECO:0000269|PubMed:25714705, ECO:0000269|PubMed:26865629}. This is the function of ENSG00000187258 (NPSR1, neuropeptide S receptor 1).