The function of H1-0 (H1.0 linker histone, Ensembl gene identifier ENSG00000189060) is as follows. Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:33238161). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:33238161). The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division (PubMed:7374750). {ECO:0000269|PubMed:33238161, ECO:0000269|PubMed:7374750}.