The function of ENSG00000197646 (PDCD1LG2, programmed cell death 1 ligand 2) is as follows. Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11224527, PubMed:12538684). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed:11224527). {ECO:0000269|PubMed:11224527, ECO:0000269|PubMed:12538684}.