The function of PLCG2 (phospholipase C gamma 2, Ensembl gene identifier ENSG00000197943) is as follows. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:19394299, PubMed:23000145). It is a crucial enzyme in transmembrane signaling (PubMed:23000145). .