Lysosomal exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex (PubMed:14695530, PubMed:25153125, PubMed:37205763, PubMed:8985184, PubMed:9054950). Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:14695530, ECO:0000269|PubMed:25153125, ECO:0000269|PubMed:37205763, ECO:0000269|PubMed:8985184, ECO:0000269|PubMed:9054950}. This is the function of ENSG00000204386 (NEU1, neuraminidase 1).